Hsp90 is one of the most important chaperones involved in regulating the maturation of
more than 300 client proteins, many of which are closely associated with refractory diseases …

Lung cancer is the most frequent cancer with an aggressive clinical course and high
mortality rates. Most cases are diagnosed at advanced stages when treatment options are …

Heat shock protein 90, also known as Hsp90, is an extensively preserved molecular
chaperone that performs a critical function in organizing various biological pathways and …

Abstract Long noncoding RNA KCNQ1OT1 participates in the regulation of imprinted genes
within the kcnq1 domain. But its roles in carcinogenesis and metastasis remain largely …

Abstract YTH domain family 2 (YTHDF2) is the first identified N6‐methyladenosine (m6A)
reader that regulates the status of mRNA. It has been reported that overexpressed YTHDF2 …

Molecular chaperones have recently emerged as fundamental regulators of salient
biological routines, including metabolic adaptations to environmental changes. Yet, many of …

Heat shock proteins (Hsp) are a class of stress-inducible proteins that mainly act as
molecular protein chaperones. This chaperone activity is diverse, including assisting in …

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated
oncogene in human cancer. The developments of many cancers depend on sustained …

Ribosomal S6 kinase (RSK) family is a group of serine/threonine kinases, including four
isoforms (RSK1/2/3/4). As a downstream effector of the Ras-mitogen-activated protein …

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to
existing therapies, most probably due to its extraordinary inter‐and intra‐tumor molecular …