Background We have previously reported successful induction of renal allograft tolerance in
nonhuman primates (NHP) after an initial posttransplant period of conventional …

Immune responses to allografts represent a major barrier in organ transplantation. Immune
tolerance to avoid chronic immunosuppression is a critical goal in the field, recently …

Kidney transplantation is the most common solid organ transplant and the best current
therapy for end-stage kidney failure. However, with standard immunosuppression, most …

Induction of immune tolerance is the Holy Grail in transplantation medicine and
autoimmunity. Currently, patients are required to use immunosuppressive drugs for the rest …

Background. Tolerance induction is an important goal in the field of organ transplantation.
We have sequentially modified our conditioning regimen for induction of donor-specific …

Based upon observations in murine models, we have developed protocols to induce renal
allograft tolerance by combined kidney and bone marrow transplantation (CKBMT) in non …

Regulation of allo-immune responses is proposed as a topic for investigation in the current
field of organ transplantation. As a regulator, regulatory T cells (Tregs) have received …

The perception that transplantation of hematopoietic stem cells can confer tolerance to any
tissue or organ from the same donor is widely accepted but it has not yet become a …

Hematopoietic chimerism remains the most promising strategy to bring transplantation
tolerance into clinical routine. The concept of chimerism-based tolerance aims to extend the …

Liver transplant (LT) recipients require life-long immunosuppression (IS) therapy to preserve
allograft function. The risks of chronic IS include an increased frequency of malignancy …