Eukaryotic cilia are organelles that project from the surface of cells to fulfill motility and
sensory functions. In vertebrates, the functions of both motile and immotile cilia are critical for …

At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …

Hereditary retinal blindness is caused by mutations in genes expressed in photoreceptors or
retinal pigment epithelium. Gene therapy in mouse and dog models of a primary retinal …

Centrosome-and cilia-associated proteins play crucial roles in establishing polarity and
regulating intracellular transport in post-mitotic cells. Using genetic mapping and positional …

The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …

Cilia are microtubule-based organelles that project like antennae from the surface of most
cells in the body. Motile cilia move fluid past cells, for example mucus in the airway. Non …

Pathogenic variants in the Retinitis pigmentosa GTPase regulator (RPGR) gene lead to a
clinically severe form of X-linked retinal dystrophy. However, it remains unclear why some …

While the functions of many of the proteins located in or associated with the photoreceptor
cilia are poorly understood, disruption of the function of these proteins may result in a wide …

Mammalian photoreceptors contain specialised connecting cilia that connect the inner (IS) to
the outer segments (OS). Dysfunction of the connecting cilia due to mutations in ciliary …

The last decade has witnessed an explosion in the identification of genes, mutations in
which appear sufficient to cause clinical phenotypes in humans. This is especially true for …