Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

The computational detection of similarities between protein 3D structures has become an
indispensable tool for the detection of homologous relationships, the classification of protein …

Linkers or spacers are short amino acid sequences created in nature to separate multiple
domains in a single protein. Most of them are rigid and function to prohibit unwanted …

As a major arm of the cellular immune response, CD4+ T cells are important in the control
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …

The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …

The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic
formation of immunological memory. Statistical analysis of repertoire sequencing data has …

Celiac disease is a T cell–mediated disease induced by dietary gluten, a component of
which is gliadin. 95% of individuals with celiac disease carry the HLA (human leukocyte …