The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …

Congenital cataracts, the most common cause of visual impairment and blindness in
children worldwide, have diverse etiologies. According to statistics analysis, about one …

Crystallins are the major proteins in the lens of the eye and function to maintain
transparency of the lens. Of the human crystallins, α, β, and γ, the β-crystallins remain the …

Cataracts cause vision loss through the large-scale aggregation of eye lens proteins as a
result of ageing or congenital mutations. The development of new treatments is hindered by …

The βγ-crystallins are among the most stable and long-lived proteins in the human body.
With increasing age, however, they transform to high molecular weight light-scattering …

Increased light scattering in the eye lens due to aggregation of the long-lived lens proteins,
crystallins, is the cause of cataract disease. Several mutations in the gene encoding human …

The vertebrate lens evolved to collect light and focus it onto the retina. In development, the
lens grows through massive elongation of epithelial cells possibly recapitulating the …

Monday, February 13, 2017 167a aggregation phenomena. Amorphous aggregation of the g-
crystallins in the eye lens causes a widespread disease of aging, cataract. We combined …

Age‐related lens cataract is the major cause of blindness worldwide. The mechanisms
whereby crystallins, the predominant lens proteins, assemble into large aggregates that …

Cataracts are a leading cause of vision impairment, which stem from the misfolding and
aggregation of crystallins in the eye lens. Despite its prevalence and severity, the detailed …