PharmVar GeneFocus: CYP2C19

MR Botton, M Whirl‐Carrillo… - Clinical …, 2021 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele
nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation …

Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19

AB Koopmans, MH Braakman, DJ Vinkers… - Translational …, 2021 - nature.com
Extensive migration has led to the necessity of knowledge regarding the treatment of
migrants with different ethnical backgrounds. This is especially relevant for pharmacological …

Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF …

MEG Naranjo, F Rodrigues-Soares… - Omics: a journal of …, 2018 - liebertpub.com
Abstract Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier
for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was …

Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans

F Rodrigues‐Soares, EM Peñas‐Lledó… - Clinical …, 2020 - Wiley Online Library
We present the distribution of CYP 2D6, CYP 2C9, and CYP 2C19 variants and predicted
phenotypes in 33 native and admixed populations from Ibero‐America (n> 6,000) in the …

Genetic structure of pharmacogenetic biomarkers in Brazil inferred from a systematic review and population-based cohorts: a RIBEF/EPIGEN-Brazil initiative

F Rodrigues-Soares, FSG Kehdy… - The …, 2018 - nature.com
We present allele frequencies involving 39 pharmacogenetic biomarkers studied in Brazil,
and their distribution on self-reported race/color categories that:(1) involve a mix of …

Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America

M Sosa-Macías, E Teran, W Waters, MM Fors… - 2016 - Taylor & Francis
Congress of Pharmacogenetics and Personalized Medicine. Ethnicity, clinical
implementation and regulatory environment (MESTIFAR 2016 Quito) Quito, Ecuador, 19–21 …

CYP2D6 and CYP2C19 Genes Associated with Tricontinental and Latin American Ancestry of Peruvians

AT Alvarado, M Saravia, R Losno… - Drug Metabolism …, 2023 - benthamdirect.com
Precision medicine seeks to individualize the dose from the beginning of pharmacological
therapy based on the characteristics of each patient, genes involved in the metabolic …

Genetic polymorphisms of CYP2C19 in ecuadorian population: An interethnic approach

AA Llorente, JS Garrido, ÓT Hermida, FG Andrade… - Heliyon, 2024 - cell.com
Introduction CYP2C19 is a highly polymorphic gene responsible for metabolizing commonly
used drugs. CYP2C19* 2,* 3 (loss of activity alleles) and* 17 (increased activity allele) are …

Pharmacogenetic research activity in Central America and the Caribbean: a systematic review

C Cespedes-Garro, MEG Naranjo… - …, 2016 - Taylor & Francis
Aim: The present review was aimed at analyzing the pharmacogenetic scientific activity in
Central America and the Caribbean. Materials & methods: A literature search for …

CYP450 y farmacogenética en Guatemala. Revisión narrativa

RJ Vargas, O Cobar - Ciencia, Tecnología y Salud, 2021 - revistas.usac.edu.gt
El proyecto HapMap ha generado información y preguntas sobre la diversidad genética en
las distintas pobla-ciones del mundo. En las últimas décadas, proyectos como la …