Therapeutic application of carvacrol: A comprehensive review

M Imran, M Aslam, SA Alsagaby, F Saeed… - Food science & …, 2022 - Wiley Online Library
Carvacrol is a major natural constituent and is significantly present as an essential oil in
aromatic plants and is well known for its numerous biological activities. Therapeutic …

Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB …

N Yan, Z Xu, C Qu, JJ Zhang - International Immunopharmacology, 2021 - Elsevier
Cerebrovascular disease and its risk factors cause persistent decrease of cerebral blood
flow, chronic cerebral hypoperfusion (CCH) is the major foundation of vascular cognitive …

Terpenoids and Their Biological Activities from Cinnamomum: A Review

M Wu, L Ni, H Lu, H Xu, S Zou, X Zou - Journal of Chemistry, 2020 - Wiley Online Library
Cinnamomum is a genus of the family Lauraceae, which has been recognized worldwide as
an important genus due to its beneficial uses. A great deal of research on its phytochemistry …

Carvacrol decreases blood–brain barrier permeability post-diffuse traumatic brain injury in rats

E Abbasloo, M Khaksari, M Sanjari, F Kobeissy… - Scientific Reports, 2023 - nature.com
Previously, we showed that Satureja Khuzestanica Jamzad essential oil (SKEO) and its
major component, carvacrol (CAR), 5-isopropyl-2-methylphenol, has anti-inflammatory, anti …

Neuroprotective potential and underlying pharmacological mechanism of Carvacrol for Alzheimer's and Parkinson's Diseases

H Javed, NM Mohamed Fizur… - Current …, 2023 - benthamdirect.com
The phytochemicals have antioxidant properties to counter the deleterious effects of
oxidative stress in the central nervous system and can be a promising drug candidate for …

Vitamin D improves cognitive impairment and alleviates ferroptosis via the Nrf2 signaling pathway in aging mice

J Li, Y Cao, J Xu, J Li, C Lv, Q Gao, C Zhang… - International Journal of …, 2023 - mdpi.com
Ferroptosis is an iron-dependent mode of cell death associated with the occurrence and
development of age-related neurodegenerative diseases. Currently, there are no effective …

Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia

Y Chen, H Yang, D Wang, Y Yao, T Chen, L Tao… - Biochemical and …, 2023 - Elsevier
Vascular dementia (VaD), the second most common type of dementia, is attributed to lower
cerebral blood flow. To date, there is still no available clinical treatment for VaD. The …

[HTML][HTML] Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca2+/CaMKII signal …

TT Chen, X Zhou, YN Xu, Y Li, XY Wu, Q Xiang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Vascular dementia (VD) is a common disease that occurs during human aging. Gastrodin
(GAS) has potential benefits for the prevention and treatment of VD. In the present study, we …

Therapeutic effects of carvacrol on beta‐amyloid‐induced impairments in in vitro and in vivo models of Alzheimer's disease

K Celik Topkara, E Kilinc, A Cetinkaya… - European Journal of …, 2022 - Wiley Online Library
Due to the complex nature of Alzheimer's disease (AD), it is important to investigate agents
with multiple effects in the treatment of AD. Carvacrol possesses anti‐acetylcholinesterase …

Neuroprotective effects of Sideritis trojana essential oil in AlCl3-induced amnesic rats

S Hayta, Ö Bulmuş, E Aksoz, S Uysal… - Journal of Essential Oil …, 2024 - Taylor & Francis
In this study, the effects of Sideritis trojana essential oil on memory, anxiety, and depression
were investigated in rats subjected to AlCl3-induced dementia. The major constituents of S …