Multi‐enzymatic cascade reactions: overview and perspectives

E Ricca, B Brucher… - Advanced Synthesis & …, 2011 - Wiley Online Library
Multi‐enzymatic cascade reactions, ie, the combination of several enzymatic transformations
in concurrent one‐pot processes, offer considerable advantages: the demand of time, costs …

Advances in the biology and chemistry of sialic acids

X Chen, A Varki - ACS chemical biology, 2010 - ACS Publications
Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids.
Natural existing sialic acid-containing structures are presented in different sialic acid forms …

Human milk oligosaccharides (HMOS): structure, function, and enzyme-catalyzed synthesis

X Chen - Advances in carbohydrate chemistry and biochemistry, 2015 - Elsevier
The important roles played by human milk oligosaccharides (HMOS), the third major
component of human milk, in the health of breast-fed infants have been increasingly …

Sialic acid metabolism and sialyltransferases: natural functions and applications

Y Li, X Chen - Applied microbiology and biotechnology, 2012 - Springer
Sialic acids are a family of negatively charged monosaccharides which are commonly
presented as the terminal residues in glycans of the glycoconjugates on eukaryotic cell …

Toward automated oligosaccharide synthesis

CH Hsu, SC Hung, CY Wu… - Angewandte Chemie …, 2011 - Wiley Online Library
Carbohydrates have been shown to play important roles in biological processes. The pace
of development in carbohydrate research is, however, relatively slow due to the problems …

Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease

V Padler-Karavani, H Yu, H Cao, H Chokhawala… - …, 2008 - academic.oup.com
Human heterophile antibodies that agglutinate animal erythrocytes are known to detect the
nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc). This monosaccharide cannot by …

A Multifunctional Pasteurella multocida Sialyltransferase:  A Powerful Tool for the Synthesis of Sialoside Libraries

H Yu, H Chokhawala, R Karpel, H Yu… - Journal of the …, 2005 - ACS Publications
A multifunctional sialyltransferase has been cloned from Pasteurella multocida strain P-1059
and expressed in E. coli as a truncated C-terminal His6-tagged recombinant protein …

C− C bond-forming lyases in organic synthesis

M Brovetto, D Gamenara, P Saenz Mendez… - Chemical …, 2011 - ACS Publications
Lyases are enzymes that catalyze the bond construction and breaking by means other than
hydrolysis or redox reactions. Such enzymes are particular in the sense that they only …

Enabling chemoenzymatic strategies and enzymes for synthesizing sialyl glycans and sialyl glycoconjugates

X Chen - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Sialic acids are fascinating negatively charged nine-carbon monosaccharides.
Sialic acid-containing glycans and glycoconjugates are structurally diverse, functionally …

Efficient chemoenzymatic synthesis of an N-glycan isomer library

L Li, Y Liu, C Ma, J Qu, AD Calderon, B Wu, N Wei… - Chemical …, 2015 - pubs.rsc.org
Quantification, characterization and biofunctional studies of N-glycans on proteins remain
challenging tasks due to the complexity, diversity and low abundance of these glycans. The …