Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

Phospholipids become increasingly important as formulation excipients and as active
ingredients per se. The present article summarizes particular features of commonly used …

Background Long-term administration of cyclosporin carries a risk of renal toxicity, and
immunosuppressants are associated with an increased rate of malignant disorders. We …

Background. This report describes the preclinical pharmacological profile of the new
rapamycin analog, SDZ RAD, ie, 40-O-(2-hydroxyethyl)-rapamycin. Methods. The …

Background In previous comparative studies tacrolimus was superior to the standard
formulation of ciclosporin in preventing acute rejection after renal transplantation. We have …

This brief review aims at providing some illustrative examples on the use of soft drug
delivery systems formed by surfactants, polymers, and lipids. Such delivery systems are …

The calcineurin inhibitors (CNI) cyclosporine and tacrolimus remain the backbone of
immunosuppression for most kidney transplant recipients. Despite many years of …

A major challenge in oral drug delivery is the development of novel dosage forms to promote
absorption of poorly permeable drugs across the intestinal epithelium. To date, no …

Intestinal phase I metabolism and active extrusion of absorbed drug have only recently been
recognized as major determinants of oral drug bioavailability. Both CYP3A4, the major …

The oral delivery of drugs is regarded as the optimal means for achieving therapeutic effects
owing to increased patient compliance. Unfortunately, the oral delivery route is beset with …