DAMP-sensing receptors in sterile inflammation and inflammatory diseases

T Gong, L Liu, W Jiang, R Zhou - Nature Reviews Immunology, 2020 - nature.com
The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms

K Malekmohammad, EE Bezsonov… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial
intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways …

Endothelial cell metabolism

G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Lipids in atherosclerosis: pathophysiology and the role of calculated lipid indices in assessing cardiovascular risk in patients with hyperlipidemia

M Gaggini, F Gorini, C Vassalle - International journal of molecular …, 2022 - mdpi.com
The role of lipids is essential in any phase of the atherosclerotic process, which is
considered a chronic lipid-related and inflammatory condition. The traditional lipid profile …

CD36 favours fat sensing and transport to govern lipid metabolism

Y Li, X Huang, G Yang, K Xu, Y Yin, G Brecchia… - Progress in lipid …, 2022 - Elsevier
CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a
critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 …

ROS in platelet biology: functional aspects and methodological insights

E Masselli, G Pozzi, M Vaccarezza… - International journal of …, 2020 - mdpi.com
Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet
functions. Platelet activation determines a drastic change in redox balance and in platelet …

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

Q Xiang, F Tian, J Xu, X Du, S Zhang… - Biological Reviews, 2022 - Wiley Online Library
Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis

CY Li, L Ma, B Yu - Biomedicine & pharmacotherapy, 2017 - Elsevier
Circular RNAs (circRNAs) are a novel class of RNAs generated from back-splicing and
characterized by covalently closed continuous loops. Recently, circRNAs have recently …

The dynamics of B cell aging in health and disease

J de Mol, J Kuiper, D Tsiantoulas, AC Foks - Frontiers in Immunology, 2021 - frontiersin.org
Aging is considered to be an important risk factor for several inflammatory diseases. B cells
play a major role in chronic inflammatory diseases by antibody secretion, antigen …

Pro-resolving mediators in the regulation of periodontal disease

TE Van Dyke - Molecular aspects of medicine, 2017 - Elsevier
Periodontitis is an inflammatory disease of the supporting structures of the dentition that is
initiated by bacteria that form a biofilm on the surface of the teeth. The pathogenesis of the …