Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

Breast cancer is the most common cancer among females worldwide. Several
epidemiological studies suggested the inverse correlation between the intake of vegetables …

To date, dozens of stress‐induced cellular senescence phenotypes have been reported.
These cellular senescence states may differ substantially from each other, as well as from …

The increase in world population by an average rate of 2% per year causes critical issues on
energy and foods. By 2050, food demand will increase to 35~ 56% more than in 2010 due to …

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …

Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote
tissue remodelling but can negatively affect regenerative capacities of tissues and contribute …

Naturally, in somatic cells chromosome ends (telomeres) shorten during each cell division.
This process ensures to limit proliferation of somatic cells to avoid malignant proliferation; …

Telomeres and telomerase are nowadays exploring traits on targets for anticancer therapy.
Telomerase is a unique reverse transcriptase enzyme, considered as a primary factor in …

Indole-3-carbinol (I3C) is a bioactive phytochemical abundant in cruciferous vegetables.
One of its main in vivo metabolites is 3, 3′-diindolylmethane (DIM), formed by the …