Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

The emerging nature of astrocyte diversity

BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia

C Henneberger, L Bard, A Panatier, JP Reynolds… - Neuron, 2020 - cell.com
Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by
perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in …

Astrocyte morphology: Diversity, plasticity, and role in neurological diseases

B Zhou, YX Zuo, RT Jiang - CNS neuroscience & therapeutics, 2019 - Wiley Online Library
Astrocytes are the most abundant glial cells in the central nervous system (CNS) and
participate in synaptic, circuit, and behavioral functions. The well‐developed protoplasmic …

Diversity of astrocyte functions and phenotypes in neural circuits

BS Khakh, MV Sofroniew - Nature neuroscience, 2015 - nature.com
Astrocytes tile the entire CNS. They are vital for neural circuit function, but have traditionally
been viewed as simple, homogenous cells that serve the same essential supportive roles …

Motor compensation and its effects on neural reorganization after stroke

TA Jones - Nature Reviews Neuroscience, 2017 - nature.com
Stroke instigates a dynamic process of repair and remodelling of remaining neural circuits,
and this process is shaped by behavioural experiences. The onset of motor disability …

Ca2+ signaling in astrocytes from Ip3r2−/− mice in brain slices and during startle responses in vivo

R Srinivasan, BS Huang, S Venugopal… - Nature …, 2015 - nature.com
Intracellular Ca2+ signaling is considered to be important for multiple astrocyte functions in
neural circuits. However, mice devoid of inositol triphosphate type 2 receptors (IP3R2) …

Synapse-specific astrocyte gating of amygdala-related behavior

M Martin-Fernandez, S Jamison, LM Robin… - Nature …, 2017 - nature.com
The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely
focused on neuronal function and connectivity. Astrocytes functionally interact with neurons …

Astrocytes modulate sensory-evoked neuronal network activity

J Lines, ED Martin, P Kofuji, J Aguilar… - Nature communications, 2020 - nature.com
While neurons principally mediate brain function, astrocytes are emerging as cells with
important neuromodulatory actions in brain physiology. In addition to homeostatic roles …