Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome
JS Knight, Y Kanthi - Seminars in immunopathology, 2022 - Springer
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia propelled by circulating
antiphospholipid antibodies that herald vascular thrombosis and obstetrical complications …
antiphospholipid antibodies that herald vascular thrombosis and obstetrical complications …
[HTML][HTML] The complement system and human autoimmune diseases
Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
G Girardi, J Berman, P Redecha… - The Journal of …, 2003 - Am Soc Clin Investig
Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in
the presence of antiphospholipid (aPL) Ab's. Currently, therapy for pregnant women with …
the presence of antiphospholipid (aPL) Ab's. Currently, therapy for pregnant women with …
Heparin prevents antiphospholipid antibody–induced fetal loss by inhibiting complement activation
G Girardi, P Redecha, JE Salmon - Nature medicine, 2004 - nature.com
The antiphospholipid syndrome (APS) is defined by thrombosis and recurrent pregnancy
loss in the presence of antiphospholipid (aPL) antibodies and is generally treated with …
loss in the presence of antiphospholipid (aPL) antibodies and is generally treated with …
Complement C3 activation is required for antiphospholipid antibody-induced fetal loss
VM Holers, G Girardi, L Mo, JM Guthridge… - The Journal of …, 2002 - rupress.org
The antiphospholipid syndrome (APS) is characterized by recurrent fetal loss, vascular
thrombosis, and thrombocytopenia occurring in the presence of antiphospholipid (aPL) …
thrombosis, and thrombocytopenia occurring in the presence of antiphospholipid (aPL) …
Complement in the pathophysiology of the antiphospholipid syndrome
The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy
morbidity in the presence of antiphospholipid antibodies (aPL). Complement is a system of …
morbidity in the presence of antiphospholipid antibodies (aPL). Complement is a system of …
Pregnancy loss in the antiphospholipid-antibody syndrome—a possible thrombogenic mechanism
JH Rand, XX Wu, HAM Andree… - … England Journal of …, 1997 - Mass Medical Soc
Background The mechanisms of vascular thrombosis and pregnancy loss in the
antiphospholipid-antibody syndrome are unknown. Levels of annexin V, a phospholipid …
antiphospholipid-antibody syndrome are unknown. Levels of annexin V, a phospholipid …
Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor
F Fischetti, P Durigutto, V Pellis, A Debeus, P Macor… - Blood, 2005 - ashpublications.org
We monitored the number of intravascular platelet-leukocyte aggregates (PLAs) and
thrombotic occlusions (TOs) by intravascular microscopy in the mesentery of rats receiving …
thrombotic occlusions (TOs) by intravascular microscopy in the mesentery of rats receiving …
Requirement of activation of complement C3 and C5 for antiphospholipid antibody–mediated thrombophilia
SS Pierangeli, G Girardi, M Vega‐Ostertag… - Arthritis & …, 2005 - Wiley Online Library
Objective Antiphospholipid antibodies (aPL) have been shown to induce thrombosis,
activate endothelial cells, and induce fetal loss. The pathogenesis of aPL‐induced …
activate endothelial cells, and induce fetal loss. The pathogenesis of aPL‐induced …
[HTML][HTML] Antiphospholipid syndrome: complement activation, complement gene mutations, and therapeutic implications
Antiphospholipid syndrome (APS) is an acquired thromboinflammatory disorder
characterized by the presence of antiphospholipid antibodies as well as an increased …
characterized by the presence of antiphospholipid antibodies as well as an increased …