The role of microbiome in brain development and neurodegenerative diseases
V Nandwana, NK Nandwana, Y Das, M Saito, T Panda… - Molecules, 2022 - mdpi.com
Hundreds of billions of commensal microorganisms live in and on our bodies, most of which
colonize the gut shortly after birth and stay there for the rest of our lives. In animal models …
colonize the gut shortly after birth and stay there for the rest of our lives. In animal models …
Boron-Containing heterocycles as promising pharmacological agents
The incorporation of the “magic” boron atom has been established as an important new
strategy in the field of medicinal chemistry as boron compounds have been shown to form …
strategy in the field of medicinal chemistry as boron compounds have been shown to form …
Synthesis, In Silico, In Vivo, and Ex Vivo Evaluation of a Boron-Containing Quinolinate Derivative with Presumptive Action on mGluRs
ME Cuevas-Galindo, BA Rubio-Velázquez… - Inorganics, 2023 - mdpi.com
In the brain, canonical excitatory neurotransmission is mediated by L-glutamate and its
ionotropic (iGluR) and metabotropic (mGluR) receptors. The wide diversity of these often …
ionotropic (iGluR) and metabotropic (mGluR) receptors. The wide diversity of these often …
Identification of new hit to lead magmas inhibitors as potential therapeutics for glioblastoma
In continuation of our previous efforts for the development of potent small molecules against
brain cancer, herein we synthesized seventeen new compounds and tested their anti …
brain cancer, herein we synthesized seventeen new compounds and tested their anti …
Design and Synthesis of New Boron-Based Benzo [c][1, 2, 5] oxadiazoles and Benzo [c][1, 2, 5] thiadiazoles as Potential Hypoxia Inhibitors
Benzo [c][1, 2, 5] oxadiazoles and benzo [c][1, 2, 5] thiadiazoles are recognized to possess
potent pharmacological activities including anticancer potential. In continuation of our …
potent pharmacological activities including anticancer potential. In continuation of our …
A novel procedure for the synthesis of borylated quinolines and its application in the development of potential boron-based homeodomain interacting protein kinase 2 …
Herein, we demonstrate a Pd catalyzed C-4 borylation of structurally complex
chloroquinolines with bis (pinacolato) diboron under relatively simple and efficient …
chloroquinolines with bis (pinacolato) diboron under relatively simple and efficient …