The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a
downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes …

Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …

The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor …

It is unknown why only a minority of circulating tumor cells trapped in lung capillaries form
metastases and involvement of immune cells remains uncertain. A novel model has been …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key cascade downstream
of several protein kinases, especially membrane-bound receptor tyrosine kinases, including …

The proline-rich Akt substrate of 40 kDa (PRAS40) acts at the intersection of the Akt-and
mammalian target of rapamycin (mTOR)-mediated signaling pathways. The protein kinase …

Signaling through the mammalian target of rapamycin complex 1 (mTORC1) is positively
regulated by amino acids and insulin. PRAS40 associates with mTORC1 (which contains …

Rapid advances have been made in our knowledge of the commonest genetic and
epigenetic alterations found in human sporadic melanomas. Valuable recent contributions …

Metastatic melanoma is notoriously one of the most difficult cancers to treat. Although many
therapeutic regimens have been tested, very few achieve response rates greater than 25 …

Melanoma cells are highly resistant to anoikis, a form of apoptosis induced in nonadherent/
inappropriate adhesion conditions. Depleting B-RAF or the prosurvival Bcl-2 family protein …