Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

T-type, low-voltage activated, calcium channels, now designated Cav3 channels, are
involved in a wide variety of physiological functions, especially in nervous systems. Their …

Among the ten subtypes of mammalian voltage-gated calcium (Ca v) channels, Ca v 3.1–Ca
v 3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of …

The Cav3. 2 subtype of T-type calcium channels has been targeted for developing
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …

T-type channels are low-voltage-activated calcium channels that contribute to a variety of
cellular and physiological functions, including neuronal excitability, hormone and …

Voltage-gated calcium channels are important mediators of calcium influx into electrically
excitable cells. The amount of calcium entering through this family of channel proteins is not …

The putative cache (Ca2+ channel and chemotaxis receptor) domain containing 1
(CACHD1) protein has predicted structural similarities to members of the α2δ voltage-gated …

Although dihydropyridines are widely used for the treatment of vasospasm, their
effectiveness is questionable, suggesting that other voltage-dependent calcium channels …

Trigeminal neuralgia is a rare and debilitating disorder that affects one or more branches of
the trigeminal nerve, leading to severe pain attacks and a poor quality of life. It has been …

Four-domain voltage-gated Ca2+ (Cav) channels play fundamental roles in the nervous
system, but little is known about when or how their unique properties and cellular roles …