Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Engineering aspects of lipid-based delivery systems: In vivo gene delivery, safety criteria, and translation strategies

I Eş, A Thakur, AM Khaneghah, C Foged… - Biotechnology …, 2024 - Elsevier
Defects in the genome cause genetic diseases and can be treated with gene therapy. Due to
the limitations encountered in gene delivery, lipid-based supramolecular colloidal materials …

Advances in the structural design of polyelectrolyte complex micelles

AE Marras, JM Ting, KC Stevens… - The Journal of Physical …, 2021 - ACS Publications
Polyelectrolyte complex micelles (PCMs) are a unique class of self-assembled nanoparticles
that form with a core of associated polycations and polyanions, microphase-separated from …

Effect of charged block length mismatch on double diblock polyelectrolyte complex micelle cores

KC Stevens, AE Marras, TR Campagna, JM Ting… - …, 2023 - ACS Publications
Polyelectrolyte complex micelles are hydrophilic nanoparticles that self-assemble in
aqueous environments due to associative microphase separation between oppositely …

Zwitterionic Polymer-Decorated Lipid Nanoparticles for mRNA Delivery in Mammalian Cells

P Khunsuk, C Pongma, T Palaga, VP Hoven - Biomacromolecules, 2023 - ACS Publications
Lipid nanoparticles (LNPs) play a key role in the effective transport of mRNA into cells for
protein translation. Despite the stealthiness of poly (ethylene glycol)(PEG) that helps protect …

100th anniversary of macromolecular science viewpoint: Attractive soft matter: Association kinetics, dynamics, and pathway complexity in electrostatically …

CCM Sproncken, JR Magana, IK Voets - ACS Macro Letters, 2021 - ACS Publications
Electrostatically coassembled micelles constitute a versatile class of functional soft materials
with broad application potential as, for example, encapsulation agents for nanomedicine …

[HTML][HTML] Functional nano-objects by electrostatic self-assembly: Structure, switching, and photocatalysis

A Krieger, A Zika, F Gröhn - Frontiers in Chemistry, 2022 - frontiersin.org
The design of functional nano-objects by electrostatic self-assembly in solution signifies an
emerging field with great potential. More specifically, the targeted combination of …

Physical property scaling relationships for polyelectrolyte complex micelles

AE Marras, TR Campagna, JR Vieregg… - Macromolecules, 2021 - ACS Publications
Polyelectrolyte complex micelles (PCMs) are self-assembled nanoparticles formed by
associative phase separation of hydrophilic neutral–charged block copolymers and …

SAXS methods for investigating macromolecular and self-assembled polyelectrolyte complexes

AB Marciel, S Srivastava, JM Ting, MV Tirrell - Methods in Enzymology, 2021 - Elsevier
Polyelectrolyte complexation is driven by associative interactions between oppositely
charged polyelectrolytes, resulting in formation of a macroscopic polymer dense phase and …

The Effect of Polyelectrolyte Architecture on Polyelectrolyte Complexation

KC Stevens - 2023 - search.proquest.com
Polyelectrolyte complexes (PECs) form spontaneously upon mixing aqueous solutions of
oppositely charged polymers, forming a polymer rich complex phase and polymer poor …