Apoptosis plays a vital role in cell homeostasis during development and disease. Bcl-x, a
member of the Bcl-2 family of proteins, is a mitochondrial transmembrane protein that …

Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and
BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins …

Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both
disease etiology and targeted intervention are needed. A total of 109 micro-dissected PDA …

RNA-binding motif protein 10 (RBM10) is a frequently mutated tumor suppressor in lung
adenocarcinoma (LUAD). Yet, it remains unknown whether cancer-derived mutant RBM10 …

Nuclear speckles are small, membrane-less organelles that reside within the nucleus.
Nuclear speckles serve as a regulatory hub coordinating complex RNA metabolism steps …

ABSTRACT RBM10 is an RNA binding protein and alternative splicing regulator frequently
mutated in lung adenocarcinomas. Recent results indicate that RBM10 inhibits proliferation …

RBM10 is a nuclear RNA-binding protein (RBP) that regulates the alternative splicing of
primary transcripts. Recently, research on RBM10 has become increasingly active owing to …

RNA-binding proteins (RBPs) play key roles in a wide range of physiological and
pathological processes. To facilitate the investigation of RBP functions and disease …

The human immune response is a complex process that responds to numerous exogenous
antigens in preventing infection by microorganisms, as well as to endogenous components …

Molecularly targeted cancer therapy has improved outcomes for patients with cancer with
targetable oncoproteins, such as mutant EGFR in lung cancer. Yet, the long-term survival of …