Stress and the nonsense-mediated RNA decay pathway
AE Goetz, M Wilkinson - Cellular and Molecular Life Sciences, 2017 - Springer
Cells respond to internal and external cellular stressors by activating stress-response
pathways that re-establish homeostasis. If homeostasis is not achieved in a timely manner …
pathways that re-establish homeostasis. If homeostasis is not achieved in a timely manner …
Roles for GADD45 in development and cancer
Abstract The Growth Arrest and DNA Damage-inducible 45 (GADD45) family of proteins are
critical stress sensors that mediate various cellular responses, including DNA repair, cell …
critical stress sensors that mediate various cellular responses, including DNA repair, cell …
Programmable RNA targeting using CasRx in flies
CRISPR-Cas genome editing technologies have revolutionized the fields of functional
genetics and genome engineering, but with the recent discovery and optimization of RNA …
genetics and genome engineering, but with the recent discovery and optimization of RNA …
A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock
Background The molecular mechanisms that determine the organism's response to a variety
of doses and modalities of stress factors are not well understood. Results We studied effects …
of doses and modalities of stress factors are not well understood. Results We studied effects …
Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability
The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal
and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular …
and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular …
Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFκB, GADD45α, and MAPK8 genes
B Raposa, R Pónusz, G Gerencsér… - Physiology …, 2016 - akjournals.com
It has been reported that some of the food additives may cause sensitization, inflammation of
tissues, and potentially risk factors in the development of several chronic diseases. Thus, we …
tissues, and potentially risk factors in the development of several chronic diseases. Thus, we …
Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system
EN Plyusnina, MV Shaposhnikov, AA Moskalev - Biogerontology, 2011 - Springer
The GADD45 protein family plays an important role in stress signaling and participates in the
integration of cellular response to environmental and physiological factors. GADD45 …
integration of cellular response to environmental and physiological factors. GADD45 …
Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs
Background Regeneration is the ability of an organism to rebuild a body part that has been
damaged or amputated, and can be studied at the molecular level using model organisms …
damaged or amputated, and can be studied at the molecular level using model organisms …
Injury activates a dynamic cytoprotective network to confer stress resilience and drive repair
H Weavers, W Wood, P Martin - Current Biology, 2019 - cell.com
In healthy individuals, injured tissues rapidly repair themselves following damage. Within a
healing skin wound, recruited inflammatory cells release a multitude of bacteriocidal factors …
healing skin wound, recruited inflammatory cells release a multitude of bacteriocidal factors …
Gadd45a is an RNA binding protein and is localized in nuclear speckles
YA Sytnikova, AV Kubarenko, A Schäfer, ANR Weber… - PloS one, 2011 - journals.plos.org
Background The Gadd45 proteins play important roles in growth control, maintenance of
genomic stability, DNA repair, and apoptosis. Recently, Gadd45 proteins have also been …
genomic stability, DNA repair, and apoptosis. Recently, Gadd45 proteins have also been …