[HTML][HTML] Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier
L Maram, JM Michael, H Politte, VS Srirama… - European Journal of …, 2025 - Elsevier
Inhibition of mitochondrial pyruvate transport via the mitochondrial pyruvate carrier (MPC)
has shown beneficial effects in treating metabolic diseases, certain cancers, various forms of …
has shown beneficial effects in treating metabolic diseases, certain cancers, various forms of …
[HTML][HTML] Interference with mitochondrial function as part of the antifibrogenic effect of Rilpivirine: A step towards novel targets in hepatic stellate cell activation
AM Benedicto, F Lucantoni, I Fuster-Martínez… - Biomedicine & …, 2024 - Elsevier
Activated hepatic stellate cells (aHSCs), the main perpetrators of liver fibrosis, are a
promising therapeutic target in the treatment of chronic liver disease. During liver injury …
promising therapeutic target in the treatment of chronic liver disease. During liver injury …
[HTML][HTML] Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis
Myofibroblasts are key cellular effectors of corneal wound healing from trauma, surgery, or
infection. However, their persistent deposition of disorganized extracellular matrix can also …
infection. However, their persistent deposition of disorganized extracellular matrix can also …
Recent Advances in Mitochondrial Pyruvate Carrier Inhibitors
Y Huang, H Zhang, X Peng, Q Zhang - Pharmaceutical Fronts, 2024 - thieme-connect.com
The mitochondrial pyruvate carrier (MPC) exists in the mitochondria inner membrane which
transports pyruvate to the mitochondrial matrix. Evidence shows that MPC is the …
transports pyruvate to the mitochondrial matrix. Evidence shows that MPC is the …
Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis
Recent studies demonstrate that liver secretory proteins, also known as hepatokines,
regulate normal development, obesity, and simple steatosis to non-alcoholic steatohepatitis …
regulate normal development, obesity, and simple steatosis to non-alcoholic steatohepatitis …