Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

M Talebi, M Talebi, T Farkhondeh… - Cancer Cell …, 2021 - Springer
Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has
anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and …

Piperazine heterocycles as potential anticancer agents: A review

M Al-Ghorbani, MA Gouda, M Baashen… - Pharmaceutical …, 2022 - Springer
Cancer is a rapid, out of control, and proliferation pathology of ordinary cells, which has
become one of the most infamous and aggressive health afflictions worldwide. Molecular …

Nose-to-brain delivery of chrysin transfersomal and composite vesicles in doxorubicin-induced cognitive impairment in rats: Insights on formulation, oxidative stress …

SS Ibrahim, OGA Elseoud, MH Mohamedy, MM Amer… - …, 2021 - Elsevier
Many cancer survivors suffer from chemotherapy-induced cognitive impairment known as
'Chemobrain'. Doxorubicin-topoisomerase II inhibitor-is widely used in breast cancer …

Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer …

MF Ahmed, EY Santali, R El-Haggar - Journal of enzyme inhibition …, 2021 - Taylor & Francis
New piperazine–chalcone hybrids and related pyrazoline derivatives have been designed
and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) …

Piperazine skeleton in the structural modification of natural products: a review

RH Zhang, HY Guo, H Deng, J Li… - Journal of enzyme …, 2021 - Taylor & Francis
Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA)

S Lin, JJ Koh, TT Aung, WLW Sin, F Lim… - Journal of Medicinal …, 2017 - ACS Publications
A new series of semisynthetic flavone-based small molecules mimicking antimicrobial
peptides has been designed from natural icaritin to combat drug-resistant Gram-positive …

Design, synthesis, molecular docking, molecular dynamic simulation, and MMGBSA analysis of 7-O-substituted 5-hydroxy flavone derivatives

KB Patel, RV Patel, I Ahmad, D Rajani… - Journal of …, 2023 - Taylor & Francis
A series of chrysin derivatives were designed, synthesized, and evaluated for their
antibacterial activity against four different bacterial strains. We have synthesized new propyl …

An overview of piperazine scaffold as promising nucleus for different therapeutic targets

A Sharma, S Wakode, F Fayaz… - Current …, 2020 - ingentaconnect.com
Piperazine scaffolds are a group of heterocyclic atoms having pharmacological values and
showing significant results in pharmaceutical chemistry. Piperazine has a flexible core …

Targeted delivery and anticancer effects of Chrysin-loaded chitosan-folic acid coated solid lipid nanoparticles in pancreatic malignant cells

A Farhadi, M Homayouni Tabrizi… - Journal of …, 2023 - Taylor & Francis
The aim of this survey was to load Chrysin (CHY) on solid lipid nanoparticles (SLNs) and
decorate the nanoparticles with folate-bound chitosan to increase the effectiveness of the …

Chrysin attenuates high glucose-induced BMSC dysfunction via the activation of the PI3K/AKT/Nrf2 signaling pathway

Y Li, X Wang - Drug Design, Development and Therapy, 2022 - Taylor & Francis
Purpose High glucose environment in diabetes mellitus induces the dysfunction of bone
marrow-derived mesenchymal stromal cells (BMSCs) and impairs bone regeneration …