Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality
worldwide. The suboptimal effect of currently used therapeutic approaches administered via …

The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular,
dense, and occluded tissue structure. Despite numerous clinical reports and animal studies …

Introduction and aim Olmesartan medoxomil (OLM) is an antihypertensive drug with low oral
bioavailability due to extensive first-pass metabolism. This study aimed to prepare transetho …

Treating a nail infection like onychomycosis is challenging as the human nail plate acts as a
formidable barrier against all drug permeation. Available oral and topical treatments have …

Aims The effect of surface-modification of Tamoxifen (Tam)-loaded-niosomes on drug
cytotoxicity and bio-distribution, via functionalization with chitosan and/or PEGylation, was …

Solid lipid nanoparticles (SLNs) are prospective carriers for oral delivery of poorly soluble
drugs with low bioavailability. Therefore, the study aimed at developing carvedilol (CVD) in …

Skin is considered the most accessible organ of the body because of its underlying capillary
network. However, stratum corneum (SC), the upper most layer of skin, represents major …

The aim of the present study is to enhance the skin penetration and deposition of 8-
methoxypsoraln (8-MOP) via niosomal vesicles to increase its local efficacy and safety. 8 …

This study aimed to make a formulation and statistical optimization of transethosomal
formulations of rosuvastatin (ROS) to enhance its topical wound healing efficiency. Design …

Drug delivery through the skin improves solubility, bioavailability, and unwanted systemic
side effects of the drug. The selection of a suitable carrier is a challenging process. The …