Leishmania parasites cause human tegumentary and visceral infections that are commonly
referred to as leishmaniasis. Despite the high incidence and prevalence of cases …

Matrix metalloproteinases (MMPs) are associated with processes of tissue remodeling and
are expressed in all infections with protozoan parasites. We here report the status of MMP …

Introduction The aim of this study was to investigate the role of the proinflammatory axis TNF-
α–TNFR1 in experimentally induced periapical inflammation and bone resorption in mice …

Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic
infections affecting millions of people across the subtropics. Symptoms range from the more …

IFN-γ, a type 2 interferon and a cytokine, is critical for both innate and adaptive immunity. IFN-
γ binds to the IFN-γRs on the cell membrane of macrophages, signals through JAK1-STAT-1 …

Leishmania is the eukaryotic parasite responsible for leishmaniases, a spectrum of diseases
that puts at risk roughly 350 millions of people in 98 countries according to the Drugs for …

Neglected parasitic diseases affect millions of people worldwide, resulting in high morbidity
and mortality. Among other parasitic diseases, leishmaniasis remains an important public …

Recent efforts in the study of vector-borne parasitic diseases (VBPDs) have emphasized an
increased consideration for preventing drug resistance and promoting the environmental …

Recently, there has been a renewed interest in the development of new drugs for the
treatment of leishmaniasis. This has spurred the need for pharmacodynamic markers to …

Leishmaniasis is considered a serious public health problem and the current available
therapy has several disadvantages, which makes the search for new therapeutic targets and …