Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by
cancer cells from many tumor types, and is a component of the pH regulatory system …

The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …

Pathological conditions in the central nervous system, including stroke and trauma, are often
exacerbated by cerebral edema. We recently identified a nonselective cation channel, the …

Hypoxia is a common pathophysiological occurrence with a profound impact on the cellular
transcriptome. The consequences of hypoxia-induced or hypoxia-repressed gene …

The vast majority of women with advanced ovarian cancer will ultimately relapse and
develop a drug-resistant disease with an overall 5-year survival of< 50%. Unfortunately, the …

0Transcriptional activation by hypoxia is mediated by the hypoxia-inducible factor (HIF) via
binding to the hypoxia-responsive element (HRE). Hypoxia in solid tumors associates with …

Carbonic anhydrase IX (CAIX) is a membrane-associated carbonic anhydrase (CA), strongly
induced by hypoxia. CAIX is overexpressed in a variety of tumor types and associated with …

Abstract In 2000, Douglas Hanahan and Robert Weinberg published a review detailing the
six hallmarks of cancer. These are six phenotypes that a tumour requires in order to become …

Purpose: Overexpression of β III tubulin has been involved in paclitaxel resistance in several
experimental models. We investigated the role of β III tubulin as predictor of clinical outcome …