Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

The International HapMap Project was designed to create a genome-wide database of
patterns of human genetic variation, with the expectation that these patterns would be useful …

Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and …

The diagnosis of inflammatory bowel disease (IBD) with its 2 main subforms, Crohn's
disease and ulcerative colitis, is based on clinical, endoscopic, radiologic, and histologic …

Extraordinary technical advances in the field of human genetics over the past few years
have catalyzed an explosion of new information about the genetics of human autoimmunity …

Objective: Attention deficit hyperactivity disorder (ADHD) is a highly heritable
neuropsychiatric disorder. In the present study, the authors investigated the presence of …

Apoptosis happens continuously for millions of cells along with the active removal of
apoptotic debris in order to maintain tissue homeostasis. In this respect, efferocytosis, ie, the …

Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we
investigated 50 previously reported susceptibility loci in a German sample of individuals with …

From epidemiological data, based on concordance data in family studies, via linkage
analysis to genome-wide association studies, we and others have accumulated robust …