Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria
by protein translocases. Yet, mitochondria contain their own genome and gene expression …

The endoplasmic reticulum (ER) membrane complex (EMC) cooperates with the Sec61
translocon to co-translationally insert a transmembrane helix (TMH) of many multi-pass …

Membrane protein biogenesis faces the challenge of chaperoning hydrophobic
transmembrane helices for faithful membrane insertion. The guided entry of tail-anchored …

Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-
prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has …

Members of the evolutionarily conserved Oxa1/Alb3/YidC family mediate membrane protein
biogenesis at the mitochondrial inner membrane, chloroplast thylakoid membrane, and …

Members of the Oxa1 superfamily perform membrane protein insertion in bacteria, the
eukaryotic endoplasmic reticulum (ER), and endosymbiotic organelles. Here, we review …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

Mitochondrial function depends on the correct synthesis, transport, and assembly of proteins
and cofactors of the electron transport chain. The initial idea that the respiratory chain …

The YidC/Alb3/Oxa1 family functions in the insertion and folding of proteins in the bacterial
cytoplasmic membrane, the chloroplast thylakoid membrane, and the mitochondrial inner …