When Szent-Györgyi called water the “matrix of life”, 1 he was echoing an old sentiment.
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …

Anatomy of the antibody molecule - ScienceDirect Skip to main contentSkip to article Elsevier
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Page 1 flexible Bodies the role of immunity in American Culture From the Days of Polio to the
Age of AIDS EMILY MARTIN Page 2 Page 3 FLEXIBLE BODIES This One T4PE-RK5-DQ53 …

Molecular nanotechnology has been defined as the three-dimensional positional control of
molecular structure to create materials and devices to molecular precision. The human body …

Rodent monoclonal antibodies have been “humanized” or “reshaped” for therapy by
transplanting the antigen-binding loops from their variable domains onto the β-sheet …

We describe a process, based on display of antibodies on the surface of filamentous
bacteriophage, for selecting antibodies either by their affinity for antigen or by their kinetics …

An altered antibody is produced by replacing the complementarity determining regions
(CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different …

The long-held views on lock-and-key versus induced fit in binding arose from the notion that
a protein exists in a single, most stable conformation, dictated by its sequence. However, in …

Recent data have highlighted the enigmatic role that water plays in biomolecular complexes.
Water at the interface of a complex can increase the promiscuity of an interaction, yet it can …

Initiation and affinity maturation of the humoral immune response is driven by antigen
interaction with BCR. To study how signaling and antigen presentation through BCR depend …