Neutrophils or polymorphonuclear leukocytes (PMN) are key participants in the innate
immune response for their ability to execute different effector functions. These cells express …

Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …

The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …

NADPH oxidase (NOX) isoforms together have multiple functions that are important for
normal physiology and have been implicated in the pathogenesis of a broad range of …

Human neutrophils constitutively undergo apoptosis and this process is critical for the
resolution of inflammation. Whilst neutrophil apoptosis can be modulated by a wide variety …

Leukocyte responsiveness to LPS is dependent upon CD14 and receptors of the Toll-like
receptor (TLR) family. Neutrophils respond to LPS, but conflicting data exist regarding LPS …

Analyses of neutrophil death mechanisms have revealed many similarities with other cell
types; however, a few important molecular features make these cells unique executors of …

Rheumatoid arthritis is the most common inflammatory joint disease. The etiopathogenesis
of this condition has been classically explained by a T cell-driven process. However, recent …

Neutrophil constitutive death is a critical cellular process for modulating neutrophil number
and function, and it plays an essential role in neutrophil homeostasis and the resolution of …

Immunotherapy aiming to rescue or boost antitumor immunity is an emerging strategy for
treatment of cancers. The efficacy of immunotherapy is strongly controlled by the …