Discovery of urinary biomarkers

T Pisitkun, R Johnstone, MA Knepper - Molecular & cellular proteomics, 2006 - ASBMB
A myriad of proteins and peptides can be identified in normal human urine. These are
derived from a variety of sources including glomerular filtration of blood plasma, cell …

Physiological conditions can be reflected in human urine proteome and metabolome

J Wu, Y Gao - Expert review of proteomics, 2015 - Taylor & Francis
Biomarkers are the measurable changes associated with physiological or
pathophysiological processes. Urine, unlike blood, lacks mechanisms for maintaining …

Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease

DM Good, P Zürbig, A Argiles, HW Bauer… - Molecular & cellular …, 2010 - ASBMB
Because of its availability, ease of collection, and correlation with physiology and pathology,
urine is an attractive source for clinical proteomics/peptidomics. However, the lack of …

Current state of the art for enhancing urine biomarker discovery

M Harpole, J Davis, V Espina - Expert review of Proteomics, 2016 - Taylor & Francis
Introduction: Urine is a highly desirable biospecimen for biomarker analysis because it can
be collected recurrently by non-invasive techniques, in relatively large volumes. Urine …

Advances in urinary proteome analysis and biomarker discovery

D Fliser, J Novak, V Thongboonkerd… - Journal of the …, 2007 - journals.lww.com
Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still
challenges in clinical nephrology. Definition of biomarkers on the basis of proteome …

A comprehensive map of the human urinary proteome

A Marimuthu, RN O'Meally, R Chaerkady… - Journal of proteome …, 2011 - ACS Publications
The study of the human urinary proteome has the potential to offer significant insights into
normal physiology as well as disease pathology. The information obtained from such studies …

CE‐MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics

JJ Coon, P Zürbig, M Dakna… - Proteomics–Clinical …, 2008 - Wiley Online Library
Owing to its availability, ease of collection, and correlation with pathophysiology of diseases,
urine is an attractive source for clinical proteomics. However, many proteomic studies have …

Practical points in urinary proteomics

V Thongboonkerd - Journal of proteome research, 2007 - ACS Publications
During the proteomic era, one of the most rapidly growing areas in biomedical research is
biomarker discovery, particularly using proteomic technologies. Urinary proteomics has …

Biomarker discovery by CE‐MS enables sequence analysis via MS/MS with platform‐independent separation

P Zürbig, MB Renfrow, E Schiffer, J Novak… - …, 2006 - Wiley Online Library
CE‐MS is a successful proteomic platform for the definition of biomarkers in different body
fluids. Besides the biomarker defining experimental parameters, CE migration time and …

Exploring the hidden human urinary proteome via ligand library beads

A Castagna, D Cecconi, L Sennels… - Journal of proteome …, 2005 - ACS Publications
The human urinary proteome has been reassessed and re-evaluated via a novel
concentration/equalization technique, exploiting beads coated with hexameric peptide …