Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation
MX Li, XT Wu, WQ Jing, WK Hou, S Hu, W Yan - Cell Death & Disease, 2023 - nature.com
Metabolic heterogeneity of tumor microenvironment (TME) is a hallmark of cancer and a big
barrier to cancer treatment. Cancer cells display diverse capacities to utilize alternative …
barrier to cancer treatment. Cancer cells display diverse capacities to utilize alternative …
MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
YP Abudu, A Kournoutis, HB Brenne, T Lamark… - Molecular Cell, 2024 - cell.com
Autophagy, an important quality control and recycling process vital for cellular homeostasis,
is tightly regulated. The mTORC1 signaling pathway regulates autophagy under conditions …
is tightly regulated. The mTORC1 signaling pathway regulates autophagy under conditions …
The Spectrum of Renal “TFEopathies”: Flipping the mTOR Switch in Renal Tumorigenesis
The mammalian target of Rapamycin complex 1 (mTORC1) is a serine/threonine kinase that
couples nutrient and growth factor signaling to the cellular control of metabolism and plays a …
couples nutrient and growth factor signaling to the cellular control of metabolism and plays a …
Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphoma
Y Liu, Y Zhu, H Chen, J Zhou, P Niu, D Shi - … Complementary Medicine and …, 2023 - Springer
Background mTORC1 (mechanistic target of rapamycin complex 1) is associated with
lymphoma progression. Oncogenic RRAGC (Rag guanosine triphosphatase C) mutations …
lymphoma progression. Oncogenic RRAGC (Rag guanosine triphosphatase C) mutations …
The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress
P Holfelder, L Hensen, MT Prentzell, PR Navas… - bioRxiv, 2023 - biorxiv.org
Limited supply and catabolism restrict the essential amino acid tryptophan (Trp) in tumors.
How tumors sustain translation under Trp stress remains unclear. Unlike other amino acids …
How tumors sustain translation under Trp stress remains unclear. Unlike other amino acids …
[PDF][PDF] Tryptophan stress activates EGFR-RAS-signaling to MTORC1 and p38/MAPK to sustain translation and AHR-dependent autophagy 2
P Pfänder, L Hensen, PR Navas, M Solvay… - bioRxiv, 2023 - researchgate.net
Tryptophan stress activates EGFR-RAS-signaling to MTORC1 and p38/MAPK to sustain
translation and AHR-dependent autophagy Page 1 1 Tryptophan stress activates EGFR-RAS-signaling …
translation and AHR-dependent autophagy Page 1 1 Tryptophan stress activates EGFR-RAS-signaling …