Description: Although approximately 85 million units of red blood cells (RBCs) are
transfused annually worldwide, transfusion practices vary widely. The AABB (formerly, the …

Objective To compare the benefit and harm of restrictive versus liberal transfusion strategies
to guide red blood cell transfusions. Design Systematic review with meta-analyses and trial …

Importance More than 100 million units of blood are collected worldwide each year, yet the
indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to …

Background Whether a restrictive threshold for hemoglobin level in red-cell transfusions, as
compared with a liberal threshold, reduces postoperative morbidity and health care costs …

Acute kidney injury (formerly known as acute renal failure) is a syndrome characterised by
the rapid loss of the kidney's excretory function and is typically diagnosed by the …

Objective To develop evidence-based clinical practice recommendations regarding
transfusion practices in non-bleeding, critically ill adults. Design A task force involving 13 …

Background—Intravascular red cell hemolysis impairs nitric oxide (NO)–redox homeostasis,
producing endothelial dysfunction, platelet activation, and vasculopathy. Red blood cell …

Background There is considerable uncertainty regarding the optimal haemoglobin threshold
for the use of red blood cell (RBC) transfusions in anaemic patients. Blood is a scarce …

Background The optimal haemoglobin threshold for use of red blood cell (RBC) transfusions
in anaemic patients remains an active field of research. Blood is a scarce resource, and in …

BACKGROUND: Prior trials suggest it is safe to defer transfusion at hemoglobin levels
above 7 to 8 g/dL in most patients. Patients with acute coronary syndrome may benefit from …