[HTML][HTML] General anaesthesia, the developing brain, and cerebral white matter alterations: a narrative review

Z Wu, W Yu, Y Song, P Zhao - British Journal of Anaesthesia, 2023 - Elsevier
The potential neurotoxic impact of anaesthetic agents has been the subject of sustained
debate and continuing research. White matter, which comprises more than half of the brain …

Effect of scalp nerve block with ropivacaine on postoperative pain in pediatric patients undergoing craniotomy: A randomized controlled trial

L Ning, L Jiang, Q Zhang, M Luo, D Xu… - Frontiers in Medicine, 2022 - frontiersin.org
Background Scalp nerve block (SNB) is widely used for postoperative pain control,
intraoperative hemodynamic control, and opioid-sparing in adult craniotomies. However …

ICU patient-on-a-chip emulating orchestration of mast cells and cerebral organoids in neuroinflammation

P Saglam-Metiner, S Yanasik, YC Odabasi… - Communications …, 2024 - nature.com
Propofol and midazolam are the current standard of care for prolonged sedation in Intensive
Care Units (ICUs). However, the effects and mechanism of these sedatives in brain tissue …

Early Postnatal Exposure to Midazolam Causes Lasting Histological and Neurobehavioral Deficits via Activation of the mTOR Pathway

J Xu, J Wen, RP Mathena, S Singh… - International Journal of …, 2024 - mdpi.com
Exposure to general anesthetics can adversely affect brain development, but there is little
study of sedative agents used in intensive care that act via similar pharmacologic …