Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and
characterization of their heterocellular relationships remains incomplete. Using mass …

Newly growing evidence highlights the essential role that epitranscriptomic marks play in the
development of many cancers; however, little is known about the role and implications of …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic
adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies …

Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and
proliferation leading to the degeneration of cellular structure and function, has been …

Inflammation is a hallmark of cancer. In patients with cancer, peripheral blood myeloid
expansion, indicated by a high neutrophil-to-lymphocyte ratio, associates with shorter …

Background Drug-resistance and severe side effects of chemotherapeutic agents result in
unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role …

Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic
inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an …