A major goal of hemoglobinopathy research is to develop treatments that correct the
underlying molecular defects responsible for sickle cell disease and β-thalassemia. One …

The developmental regulation of γ‐globin gene expression has shaped research efforts to
establish therapeutic modalities for individuals affected with sickle cell disease (SCD). Fetal …

Sp/KLF family of factors regulates gene expression by binding to the CACCC/GC/GT boxes
in the DNA through their highly conserved three zinc finger domains. To investigate the role …

Human hemoglobin is a tetrameric molecule comprised of two pairs of identical polypeptide
subunits, each pair encoded by a different family of genes. The human a-like globin genes …

Strategies to induce fetal hemoglobin (HbF) synthesis for the treatment of β-
hemoglobinopathies probably involve protein modifications by histone deacetylases …

Background: Currently, the high expression of fetal hemoglobin (HbF) in sickle cell disease
is treated by hydroxyurea (HU). However, potential adverse effect regarding the use of HU is …

Pharmacological stimulation of fetal hemoglobin (HbF) expression may be a promising
approach for the treatment of beta‐thalassemia. In this study, the effects of Fructus …

Short-chain fatty acids (SCFAs; butyrate and propionate) up-regulate embryonic/fetal globin
gene expression through unclear mechanisms. In a murine model of definitive …

It has been reported that various endocrine hormones exert prominent effects on
erythropoiesis. We conducted experiments to identify the mechanisms involved in the …

E 13s 2583 523 342 a. IC50 values are the concentrations of the individual compounds at
which the cell proliferation rates are reduced by 50%. b. EC values are defined as the …