[HTML][HTML] Integrins in cancer: Emerging mechanisms and therapeutic opportunities

F Liu, Q Wu, Z Dong, K Liu - Pharmacology & therapeutics, 2023 - Elsevier
Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

[HTML][HTML] Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

M Hashemi, S Etemad, S Rezaei, S Ziaolhagh… - Biomedicine & …, 2023 - Elsevier
Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …

MicroRNA-206 in human cancer: mechanistic and clinical perspectives

LB Khasraghi, M Nouri, M Vazirzadeh, N Hashemipour… - Cellular …, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), small non-coding RNAs approximately 20–25 nt in length,
play important roles via directly binding to the corresponding 3′ UTR of target mRNAs …

Systematic review of photodynamic therapy in gliomas

T Hsia, JL Small, A Yekula, SM Batool, AK Escobedo… - Cancers, 2023 - mdpi.com
Simple Summary Malignant gliomas are of the deadliest, most hard-to-treat cancers, given
their various characteristics of aggression and infiltration as well as the location of growth …

Connexins and glucose metabolism in cancer

JC Jones, TM Bodenstine - International journal of molecular sciences, 2022 - mdpi.com
Connexins are a family of transmembrane proteins that regulate diverse cellular functions.
Originally characterized for their ability to mediate direct intercellular communication through …

Mapping the Anti-Cancer Activity of α-Connexin Carboxyl-Terminal (aCT1) Peptide in Resistant HER2+ Breast Cancer

KM Baker, M Abt, EH Doud, AL Oblak, ES Yeh - Cancers, 2024 - mdpi.com
Simple Summary Breast cancer is a leading cause of death for women worldwide. This study
aims to examine the mechanisms for the anti-cancer effects of a therapeutic peptide agent …

Gastrodin Liposomes Block Crosstalk between Astrocytes and Glioma Cells via Downregulating Cx43 to Improve Antiglioblastoma Efficacy of Temozolomide

Y Song, Q Huang, Q Pu, S Ni, W Zhu… - Bioconjugate …, 2024 - ACS Publications
The crosstalk between glioma cells and astrocytes plays a crucial role in developing
temozolomide (TMZ) resistance of glioblastomas, together with the existence of the BBB …

Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas

S Li, X Xie, F Peng, J Du… - … Journal of Oncology, 2022 - spandidos-publications.com
Gliomas are a primary types of intracranial malignancies and are characterized by a poor
prognosis due to aggressive recurrence profiles. Temozolomide (TMZ) is an auxiliary …

Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis

EE Mulkearns-Hubert, N Hajdari, ES Hong, AP Jacobs… - bioRxiv, 2024 - biorxiv.org
The coordination of cellular processes such as growth and survival relies on communication
between cells through gap junctions. Gap junction intercellular communication is driven by …

Multiple approaches for the evaluation of connexin-43 expression and function in macrophages

JC de Sousa, SACS Santos, E Kurtenbach - Journal of Immunological …, 2024 - Elsevier
Connexins are essential gap junction proteins that play pivotal roles in intercellular
communication in various organs of mammals. Connexin-43 (Cx43) is expressed in various …