Lipid nanoparticles as a promising drug delivery carrier for topical ocular therapy—an overview on recent advances

S Jacob, AB Nair, J Shah, S Gupta, SHS Boddu… - Pharmaceutics, 2022 - mdpi.com
Due to complicated anatomical and physical properties, targeted drug delivery to ocular
tissues continues to be a key challenge for formulation scientists. Various attempts are …

Oxidative stress: a suitable therapeutic target for optic nerve diseases?

F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …

Ocular surface disease: a known yet overlooked side effect of topical glaucoma therapy

RE Ruiz-Lozano, NS Azar, HM Mousa… - Frontiers in …, 2023 - frontiersin.org
Ocular surface disease (OSD), a disorder affecting the lacrimal and meibomian glands and
the corneal and conjunctival epithelium, is a well-known complication of topical glaucoma …

Immunomodulatory and antioxidant drugs in glaucoma treatment

F Buonfiglio, N Pfeiffer, A Gericke - Pharmaceuticals, 2023 - mdpi.com
Glaucoma, a group of diseases characterized by progressive retinal ganglion cell loss,
cupping of the optic disc, and a typical pattern of visual field defects, is a leading cause of …

[HTML][HTML] Innovations in Nanoemulsion Technology: Enhancing Drug Delivery for Oral, Parenteral, and Ophthalmic Applications

S Jacob, FS Kather, SHS Boddu, J Shah, AB Nair - Pharmaceutics, 2024 - mdpi.com
Nanoemulsions (NEs) are submicron-sized heterogeneous biphasic liquid systems
stabilized by surfactants. They are physically transparent or translucent, optically isotropic …

Rho-kinase inhibitors as emerging targets for glaucoma therapy

J Wang, H Wang, Y Dang - Ophthalmology and Therapy, 2023 - Springer
Glaucoma, the leading cause of irreversible blindness worldwide, is a chronic and
progressive optic neuropathy characterized by damage to the optic and retinal nerve fiber …

[HTML][HTML] Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation

M Jiang, R Guo, Y Ai, G Wang, P Tang, X Jia, B He… - JHEP Reports, 2023 - Elsevier
Background & Aims Hepatocyte transplantation has emerged as a possible treatment option
for end-stage liver disease. However, an important obstacle to therapeutic success is the low …

ROCK Inhibitors as an Alternative Therapy for Corneal Grafting: A Systematic Review

S Polopalli, A Saha, P Niri, M Kumar, P Das… - Journal of Ocular …, 2023 - liebertpub.com
Currently, corneal blindness is affecting> 10 million individuals worldwide, and there is a
significant unmet medical need because only 1.5% of transplantation needs are met globally …

The Role of Mitophagy in Glaucomatous Neurodegeneration

D Stavropoulos, MK Grewal, B Petriti, KY Chau… - Cells, 2023 - mdpi.com
This review aims to provide a better understanding of the emerging role of mitophagy in
glaucomatous neurodegeneration, which is the primary cause of irreversible blindness …

Novel cardiovascular protective effects of RhoA signaling and its therapeutic implications

JEC Soh, A Shimizu, A Sato, H Ogita - Biochemical Pharmacology, 2023 - Elsevier
Ras homolog gene family member A (RhoA) belongs to the Rho GTPase superfamily, which
was first studied in cancers as one of the essential regulators controlling cellular function …