The non-structural protein 1 of influenza virus (NS1) is a relatively small polypeptide with an
outstanding number of ascribed functions. NS1 is the main viral antagonist of the innate …

A growing number of studies indicate that host species-specific and virus strain-specific
interactions of viral molecules with the host innate immune system play a pivotal role in …

RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response
to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin …

Most viruses express one or several proteins that counter the antiviral defences of the host
cell. This is the task of non-structural protein NS1 in influenza viruses. Absent in the viral …

Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and
spreads throughout the world each year. Every year, influenza infects around 10% of the …

Abstract Cyclic GMP-AMP synthase (cGAS) is a key DNA sensor that detects aberrant
cytosolic DNA arising from pathogen invasions or genotoxic stresses. Upon binding to DNA …

Influenza viruses antagonize key immune defence mechanisms via the virulence factor non-
structural protein 1 (NS1). A key mechanism of virulence by NS1 is blocking nuclear export …

In conventional attenuated viral vaccines, immunogenicity is often suboptimal. Here we
present a systematic approach for vaccine development that eliminates interferon (IFN) …

ABSTRACT Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with
multifunctional roles in virus replication and a potent antagonist of host immune response …

During infection, the influenza A virus non-structural protein 1 (NS1) interacts with a diverse
range of viral and cellular factors to antagonize host antiviral defences and promote viral …