Recent clinical trials of gene therapy have shown remarkable therapeutic benefits and an
excellent safety record. They provide evidence for the long-sought promise of gene therapy …

T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …

Conclusions Our findings indicate that LINC00665 is involved in the NF‐κB signaling
activation in HCC cells and that the inflammatory LINC00665/PKR/NF‐κB loop plays …

T cell memory relies on the generation of antigen-specific progenitors with stem-like
properties. However, the identity of these progenitors has remained unclear, precluding a …

Abstract Current US Food and Drug Administration-approved chimeric antigen receptor
(CAR) T cells harbor the T cell receptor (TCR)-derived ζ chain as an intracellular activation …

Chronic granulomatous disease (CGD) is a rare inherited disorder of phagocytic cells,. We
report the initial results of nine severely affected X-linked CGD (X-CGD) patients who …

Low-affinity CD19 chimeric antigen receptor (CAR) T cells display enhanced expansion and
persistence, enabling fate tracking through integration site analysis. Here we show that …

Abstract Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger
profound and sustained tumor regression but their rareness poses a major hurdle to their …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

Over the last decade remarkable progress has been made in enhancing the efficacy of CAR
T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in …