Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes
In patients with drug-resistant epilepsy, electrical stimulation of the brain in response to
epileptiform activity can make seizures less frequent and debilitating. This therapy, known as …
epileptiform activity can make seizures less frequent and debilitating. This therapy, known as …
Hippocampal theta and episodic memory
Computational models of rodent physiology implicate hippocampal theta as a key modulator
of learning and memory (;), yet human hippocampal recordings have shown divergent theta …
of learning and memory (;), yet human hippocampal recordings have shown divergent theta …
Fast ripples reflect increased excitability that primes epileptiform spikes
The neuronal circuit disturbances that drive inter-ictal and ictal epileptiform discharges
remain elusive. Using a combination of extra-operative macro-electrode and micro-electrode …
remain elusive. Using a combination of extra-operative macro-electrode and micro-electrode …
Prevalence and localization of nocturnal epileptiform discharges in mild cognitive impairment
R Ciliento, K Gjini, K Dabbs, B Hermann… - Brain …, 2023 - academic.oup.com
Recent evidence shows that identifying and treating epileptiform abnormalities in patients
with Alzheimer's disease could represent a potential avenue to improve clinical outcome …
with Alzheimer's disease could represent a potential avenue to improve clinical outcome …
Closed-loop neurostimulation for epilepsy leads to improved outcomes when stimulation episodes are delivered during periods with less epileptiform activity
In patients with drug-resistant epilepsy, electrical stimulation of the brain in response to
epileptiform activity can make seizures less frequent and debilitating. When effective, this …
epileptiform activity can make seizures less frequent and debilitating. When effective, this …
Interictal epileptiform discharges contribute to word‐finding difficulty in epilepsy through multiple cognitive mechanisms
Objective Cognitive impairment often impacts quality of life in epilepsy even if seizures are
controlled. Word‐finding difficulty is particularly prevalent and often attributed to etiological …
controlled. Word‐finding difficulty is particularly prevalent and often attributed to etiological …
Highlights From the Annual Meeting of the American Epilepsy Society 2022
I Valencia, AL Alexander, DM Andrade… - 2023 - journals.sagepub.com
With more than 6000 attendees between in-person and virtual offerings, the American
Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever …
Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever …
A platform for brain network sensing and stimulation with quantitative behavioral tracking: Application to limbic circuit epilepsy
Temporal lobe epilepsy (TLE) is a common neurological disease characterized by recurrent
focal seizures. These seizures often originate from the mesial temporal limbic networks and …
focal seizures. These seizures often originate from the mesial temporal limbic networks and …
High-gamma and beta bursts in the Left Supramarginal Gyrus can accurately differentiate verbal memory states and performance
N Sawczuk, DY Rubinstein, MR Sperling… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
The left supramarginal gyrus (LSMG) may mediate attention to memory, and gauge memory
state and performance. We performed a secondary analysis of 142 verbal delayed free …
state and performance. We performed a secondary analysis of 142 verbal delayed free …
[PDF][PDF] BRAIN COMMUNICATIONS
Spontaneous inter-ictal epileptiform spikes (ie spikes) were first recognized nearly a century
ago in extracellular recordings from animals exposed to chemoconvulsants and in the EEG …
ago in extracellular recordings from animals exposed to chemoconvulsants and in the EEG …