Inhibitors of the PLK1 polo-box domain: drug design strategies and therapeutic opportunities in cancer

JM Stafford, MD Wyatt, C McInnes - Expert Opinion on Drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Polo Like Kinase 1 (PLK1) is a key regulator of mitosis and its
overexpression is frequently observed in a wide variety of human cancers, while often being …

Recent progress in luminescent materials based on lanthanide complexes intercalated synthetic clays

Y Wang, P Li, S Wang, H Li - Journal of Rare Earths, 2019 - Elsevier
Interest in lanthanide complexes in the synthetic clays remains growing considerably during
the last decades because of the attractive features of the individuals. Synthetic clays like …

Pep-Calc. com: a set of web utilities for the calculation of peptide and peptoid properties and automatic mass spectral peak assignment

S Lear, SL Cobb - Journal of computer-aided molecular design, 2016 - Springer
The ability to calculate molecular properties such as molecular weights, isoelectric points,
and extinction coefficients is vital for scientists using and/or synthesizing peptides and …

Lanthanide-based peptide-directed visible/near-infrared imaging and inhibition of LMP1

HF Chau, Y Wu, WY Fok, W Thor, WCS Cho, P Ma… - Jacs Au, 2021 - ACS Publications
A lanthanide-based peptide-directed bioprobe LnP19 (Ln= Eu or Yb) is designed as an
impressive example of a small molecule-based dual-functional probe for the EBV …

Cross talk between autophagy and apoptosis contributes to ZnO nanoparticle‐induced human osteosarcoma cell death

G He, Y Ma, Y Zhu, L Yong, X Liu… - Advanced …, 2018 - Wiley Online Library
Killing osteosarcoma cells by zinc oxide nanoparticles (NPs) and its underlying subcellular
mechanism are never studied. Here, it is found that the NPs induce cross talk between …

NaGd(MoO4)2 nanocrystals with diverse morphologies: controlled synthesis, growth mechanism, photoluminescence and thermometric properties

A Li, D Xu, H Lin, S Yang, Y Shao, Y Zhang - Scientific Reports, 2016 - nature.com
Pure tetragonal phase, uniform and well-crystallized sodium gadolinium molybdate (NaGd
(MoO4) 2) nanocrystals with diverse morphologies, eg nanocylinders, nanocubes and …

Multifunctional β-NaGdF4: Ln3+ (Ln= Yb/Er/Eu) phosphors synthesized by L-arginine assisted hydrothermal method and their multicolor tunable luminescence

Q Liu, Z Chen, F Hong, G Liu, W Yu, C Song… - Materials Research …, 2019 - Elsevier
Rare earth ions doped luminescence nanomaterials have broad applications ranging from
television tubes to biological imaging. A series of Yb 3+/Er 3+/Eu 3+ ions doped NaGdF 4 …

Construction of a phos-tag-directed self-assembled fluorescent magnetobiosensor for the simultaneous detection of multiple protein kinases

S Jiang, YX Geng, WJ Liu, ZY Wang… - Journal of Materials …, 2022 - pubs.rsc.org
Protein kinases play important roles in regulating various cellular processes and may
function as potential diagnostic and therapeutic targets for various diseases including …

Modified synthetic peptides: from therapeutics to chemosensors

C Wynne, RBP Elmes - Sensors & Diagnostics, 2024 - pubs.rsc.org
Modified synthetic peptides have emerged as an exciting avenue for enhancing therapeutic
efficacy and expanding the scope of applications in various disease contexts. Indeed, the …

[PDF][PDF] Sensors & Diagnostics

C Wynne, RBP Elmes - 2024 - researchrepository.ul.ie
Peptides are physiologically active compounds made up of short chains of amino acid (AA)
monomers connected by amide bonds (peptide bonds). The beginning of peptide chemistry …