HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

The core lipocalin, bovine β-lactoglobulin

L Sawyer, G Kontopidis - Biochimica et Biophysica Acta (BBA)-Protein …, 2000 - Elsevier
The lipocalin family became established shortly after the structural similarity was noted
between plasma retinol binding protein and the bovine milk protein, β-lactoglobulin. During …

Clustering of fluorine-substituted alcohols as a factor responsible for their marked effects on proteins and peptides

DP Hong, M Hoshino, R Kuboi… - Journal of the American …, 1999 - ACS Publications
Among various alcohols, those substituted with fluorine, such as 2, 2, 2-trifluoroethanol
(TFE) or 3, 3, 3, 3 ', 3 ', 3 '-hexafluoro-2-propanol (HFIP), have a marked potential to induce …

Molecular confinement influences protein structure and enhances thermal protein stability

DK Eggers, JS Valentine - Protein Science, 2001 - Wiley Online Library
The sol‐gel method of encapsulating proteins in a silica matrix was investigated as a
potential experimental system for testing the effects of molecular confinement on the …

Mechanical properties of single electrospun collagen type I fibers

L Yang, CFC Fitié, KO Van Der Werf, ML Bennink… - Biomaterials, 2008 - Elsevier
The mechanical properties of single electrospun collagen fibers were investigated using
scanning mode bending tests performed with an AFM. Electrospun collagen fibers with …

Challenges and perspectives in chemical synthesis of highly hydrophobic peptides

LK Mueller, AC Baumruck, H Zhdanova… - … in Bioengineering and …, 2020 - frontiersin.org
Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …

Hexafluoroisopropanol as a Bioconjugation Medium of Ultrafast, Tryptophan-Selective Catalysis

M Nuruzzaman, BM Colella, CP Uzoewulu… - Journal of the …, 2024 - ACS Publications
The past decade has seen a remarkable growth in the number of bioconjugation techniques
in chemistry, biology, material science, and biomedical fields. A core design element in …

Crowding and hydration effects on protein conformation: a study with sol-gel encapsulated proteins

DK Eggers, JS Valentine - Journal of molecular biology, 2001 - Elsevier
We are developing an experimental system for testing the effects of macromolecular
crowding and molecular confinement on protein structure. In the present study, solvent …

Group additive contributions to the alcohol-induced α-helix formation of melittin: implication for the mechanism of the alcohol effects on proteins

N Hirota, K Mizuno, Y Goto - Journal of molecular biology, 1998 - Elsevier
Detailed analysis of the effects of alcohols on proteins and peptides is important because of
its wide range of applications in many fields. Whereas melittin, a major component of …

Folding amphipathic helices into membranes: amphiphilicity trumps hydrophobicity

M Fernández-Vidal, S Jayasinghe, AS Ladokhin… - Journal of molecular …, 2007 - Elsevier
High amphiphilicity is a hallmark of interfacial helices in membrane proteins and membrane-
active peptides, such as toxins and antimicrobial peptides. Although there is general …