The sorting of proteins into the inner vesicles of multivesicular bodies is required for many
key cellular processes, which range from the downregulation of activated signalling …

The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of
several diverse cellular processes. Here, we describe the important components of this …

Spodoptera frugiperda SF-21 cells infected with Autographa californica nuclear
polyhedrosis virus mutants which lack a functional p35 gene undergo apoptosis, a type of …

Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein
ubiquitination. The c-Cbl proto-oncogene is a RING family E3 that recognizes activated …

CBL encodes a member of the Cbl family of proteins, which functions as an E3 ubiquitin
ligase. We describe a dominant developmental disorder resulting from germline missense …

Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to
loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour …

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein
tyrosine kinases which, when activated, initiate the formation of protein complexes that …

The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here
we show that iap can also prevent cell death in mammalian cells. The ability of iap to …

Protein tyrosine kinases (PTKs) coordinate a broad spectrum of cellular responses to
extracellular stimuli and cell–cell interactions during development, tissue homeostasis, and …

OSTEOCLASTIC BONE RESORPTION consists of several compli-cated processes:
osteoclast development, attachment of osteoclasts to calcified tissues, development of a …