Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Significant progress has been made in the treatment of spinal cord injury (SCI). Advances in
post-trauma management and intensive rehabilitation have significantly improved the …

Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration
of corticospinal axons and restore forelimb function after spinal cord injury; however, the …

Neural stem/progenitor cell (NSPC) grafts can integrate into sites of spinal cord injury (SCI)
and generate neuronal relays across lesions that can provide functional benefit. To …

Aligned fibrous hydrogels capable of recruiting endogenous neural stem/progenitor cells
(NSPCs) show great promise in spinal cord injury (SCI) repair. However, the hydrogels …

Spinal cord neural stem cells (NSCs) have great potential to reconstitute damaged spinal
neural circuitry, but they have yet to be generated in vitro. We now report the derivation of …

The ability to directly reprogram mature cells to alternative fates challenges concepts of how
cell identities are maintained, erased, and acquired. Recent advances in understanding and …

We used viral intersectional tools to map the entire projectome of corticospinal neurons
associated with fine distal forelimb control in Fischer 344 rats and rhesus macaques. In rats …

Transplantation of neural stem/progenitor cells (NS/PCs) derived from human induced
pluripotent stem cells (hiPSCs) is considered to be a promising therapy for spinal cord injury …

In the adult mammalian central nervous system (CNS), neurons typically fail to regenerate
their axons after injury. During development, by contrast, neurons extend axons effectively. A …