The intrinsic electrical properties and the synaptic input-output relationships of neurons are
governed by the action of voltage-dependent ion channels. The localization of specific …

The somatodendritic subthreshold A-type K+ current (ISA) in nerve cells is a critical
component of the ensemble of voltage-gated ionic currents that determine somatodendritic …

Background: NOTCH1 pathogenic variants are implicated in multiple types of congenital
heart defects including hypoplastic left heart syndrome, where the left ventricle is …

Voltage-gated potassium (Kv) channels mediate rapid, selective diffusion of K+ ions through
the plasma membrane, controlling cell excitability, secretion and signal transduction. KCNE …

Voltage-gated potassium (Kv) channels from the Kv4, or Shal-related, gene family underlie a
major component of the A-type potassium current in mammalian central neurons. We …

The transient outward current (Ito), an important contributor to transmural
electrophysiological heterogeneity, is significantly remodelled in congestive heart failure …

Inactivation of voltage‐gated ion channels is an intrinsic auto‐regulatory process necessary
to govern the occurrence and shape of action potentials and establish firing patterns in …

The dipeptidyl aminopeptidase-like protein DPPX (DPP6) associates with Kv4 potassium
channels, increasing surface trafficking and reconstituting native neuronal I SA-like …

Cardiomyocytes are endowed with a complex repertoire of ion channels, responsible for the
generation of action potentials (APs), travelling waves of electrical excitation, propagating …

Neuronal calcium sensor (NCS) proteins, a sub-branch of the calmodulin superfamily, are
expressed in the brain and retina where they transduce calcium signals and are genetically …