In this Review, we survey recent developments in the emerging field of high-speed variable-
z-focus optical elements, which are driving important innovations in advanced imaging and …

Three-dimensional fluorescence imaging has been a longstanding goal for microscopists,
made all the more challenging when aiming for a trifecta of resolution, speed, and field of …

Calcium imaging using two-photon scanning microscopy has become an essential tool in
neuroscience. However, in its typical implementation, the tradeoffs between fields of view …

Extended depth of focus (EDOF) lenses are important for various applications in
computational imaging and microscopy. In addition to enabling novel functionalities, EDOF …

Microscopic evaluation of resected tissue plays a central role in the surgical management of
cancer. Because optical microscopes have a limited depth-of-field (DOF), resected tissue is …

Optical-resolution photoacoustic microscopy can visualize wavelength-dependent optical
absorption at the cellular level. However, this technique suffers from a limited depth of field …

Multiphoton microscopy has gained enormous popularity because of its unique capacity to
provide high-resolution images from deep within scattering tissue. Here, we demonstrate …

Rapid, high-resolution volumetric imaging without moving heavy objectives or disturbing
delicate samples remains challenging. Pupil-matched remote focusing offers a promising …

Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative
focused on development of technologies for advancement of neuroscience. For the last …

The optical microscope is customarily an instrument of substantial size and expense but
limited performance. Here we report an integrated microscope that achieves optical …