Despite the high prevalence of gastrointestinal tumors, early diagnosis and treatment of
these tumors is limited by the lack of effective and specific biomarkers and therapeutic …

Hepatocellular carcinoma (HCC), the most common primary malignancy of the liver, is one
of the leading causes of cancer-related death and is associated with a poor prognosis. The …

Metastasis, the spread of a tumor or cancer from the primary site of the body to a secondary
site, is a multi-step process in cancer progression, accounting for various obstacles in …

Cancer is a multi-factor systemic malignant disease, which has seriously threatened human
health and created a heavy burden on the world economy. Metabolic reprogramming, one of …

Exploration of E3 ubiquitin ligases as potential therapeutic targets has been ongoing for two
to three decades. Various chemicals and drugs have been developed to either upregulate or …

Abstract Background Circular RNAs (circRNAs) exert crucial roles in tumor progression of
multiple cancers, including colorectal cancer (CRC). However, the functions of most …

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide due to the
lack of effective diagnosis and prognosis biomarkers and therapeutic targets, resulting in …

Malignant tumors seriously affect people's survival and prognosis. Exosomes, as vesicle
structures widely existing in human tissues and body fluids, are involved in cell-to-cell …

microRNAs (miRNAs) are a type of small endogenous non-coding RNAs composed of 20-22
nucleotides, which can regulate the expression of a gene by targeting 3'untranslated region …

Abstract Background Circular RNAs (circRNAs) are identified as a novel family of
endogenous RNA molecules through 'back-splicing'and covalently linked at the 5′ and 3 …