Global view of human protein glycosylation pathways and functions
Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …
Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications
Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare
(MAF≤ 1%) variants contribute to complex traits and disease in the general population is …
(MAF≤ 1%) variants contribute to complex traits and disease in the general population is …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
Five years of GWAS discovery
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …
experimental design of genome-wide association studies (GWASs). These studies were …
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
Objectives To identify the genetic determinants of fracture risk and assess the role of 15
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family
Glycosylation of proteins is an essential process in all eukaryotes and a great diversity in
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …
[HTML][HTML] Bone composition: relationship to bone fragility and antiosteoporotic drug effects
AL Boskey - BoneKEy reports, 2013 - ncbi.nlm.nih.gov
The composition of a bone can be described in terms of the mineral phase, hydroxyapatite,
the organic phase, which consists of collagen type I, noncollagenous proteins, other …
the organic phase, which consists of collagen type I, noncollagenous proteins, other …