Ancestral Sequence Reconstruction to Enable Biocatalytic Synthesis of Azaphilones

CH Chiang, Y Wang, A Hussain… - Journal of the …, 2024 - ACS Publications
Biocatalysis can be powerful in organic synthesis but is often limited by enzymes' substrate
scope and selectivity. Developing a biocatalytic step involves identifying an initial enzyme …

Photoinduced Pd-Catalyzed 1, 4-Dicarbofunctionalization of 1, 3-Butadienes via Aliphatic C–H Bond Elaboration

DX Wu, XY Ruan, WQ Zhang, M Sayed, ZY Han - Organic Letters, 2025 - ACS Publications
A three-component coupling strategy for 1, 4-dicarbofunctionalization of 1, 3-butadiene with
C–H bearing substrates has been developed using photoinduced Pd catalysis, with aryl …