As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Simple Summary Persistent activation of STAT3 is frequently observed in non-small cell lung
cancer and is associated with a poor prognosis. Given the multifaceted role of STAT3 …

Signal transducer and activator of transcription 3 (STAT3) plays an important role in the
occurrence and progression of tumors, leading to resistance and poor prognosis. Activation …

Prostate cancer (PCa) is a key public health problem worldwide; at diagnosis, a high
percentage of patients exhibit tumor cell invasion of adjacent tissue. STAT‑3, IL‑6 receptor …

In this review we concentrate on the recent findings describing the oncogenic potential of the
protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 …

Purpose Targeting cancer cells by modulating the immune system has become an important
new therapeutic option in many different malignancies. Inhibition of CTLA4/B7 and …

Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare extranodal lymphoma
subtype. This retrospective study elucidates the currently unknown genetic background of a …

Esophageal cancer is one of the most prevalent diseases in the world, and its prognosis
remains poor. Surgery, chemotherapy, and radiotherapy are the most common treatment …