Ocular blood flow as a clinical observation: Value, limitations and data analysis

A Harris, G Guidoboni, B Siesky, S Mathew… - Progress in retinal and …, 2020 - Elsevier
Alterations in ocular blood flow have been identified as important risk factors for the onset
and progression of numerous diseases of the eye. In particular, several population-based …

Uncertainty quantification implementations in human hemodynamic flows

G Ninos, V Bartzis, N Merlemis, IE Sarris - Computer Methods and …, 2021 - Elsevier
Background and objective Human hemodynamic modeling is usually influenced by
uncertainties occurring from a considerable unavailability of information linked to the …

Morphological and biomechanical analyses of the human healthy and glaucomatous aqueous outflow pathway: imaging-to-modeling

A Karimi, DJ Crouch, R Razaghi, JC Downs… - Computer Methods and …, 2023 - Elsevier
Abstract Background and Objective: Intraocular pressure (IOP) is maintained via a dynamic
balance between the production of aqueous humor and its drainage through the trabecular …

Viscoelastic biomechanical properties of the conventional aqueous outflow pathway tissues in healthy and glaucoma human eyes

A Karimi, R Razaghi, S Padilla, SM Rahmati… - Journal of clinical …, 2022 - mdpi.com
Background: Although the tissues comprising the ocular conventional outflow pathway have
shown strong viscoelastic mechanical response to aqueous humor pressure dynamics, the …

Cardiovascular function and ballistocardiogram: A relationship interpreted via mathematical modeling

G Guidoboni, L Sala, M Enayati… - IEEE Transactions …, 2019 - ieeexplore.ieee.org
Objective: To develop quantitative methods for the clinical interpretation of the
ballistocardiogram (BCG). Methods: A closed-loop mathematical model of the …

Machine learning–couched treatment algorithms tailored to individualized profile of patients with primary anterior chamber angle closure predisposed to the …

NI Kurysheva, OY Rodionova, AL Pomerantsev… - EPMA Journal, 2023 - Springer
Background Primary angle closure glaucoma (PACG) is still one of the leading causes of
irreversible blindness, with a trend towards an increase in the number of patients to 32.04 …

Modeling the biomechanics of the conventional aqueous outflow pathway microstructure in the human eye

A Karimi, R Razaghi, SM Rahmati, JC Downs… - Computer methods and …, 2022 - Elsevier
Background and objective Intraocular pressure (IOP) is determined by aqueous humor
outflow resistance, which is a function of the combined resistance of Schlemm's canal (SC) …

The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye

L Sala, C Prud'Homme, G Guidoboni… - International Journal …, 2024 - Wiley Online Library
We present our continuous efforts from a modeling and numerical viewpoint to develop a
powerful and flexible mathematical and computational framework called Ocular …

Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions

F Salerni, R Repetto, A Harris, P Pinsky… - PLoS …, 2019 - journals.plos.org
This work aims at investigating the interactions between the flow of fluids in the eyes and the
brain and their potential implications in structural and functional changes in the eyes of …

A low-cost Algorithm for uncertainty quantification simulations of steady-state flows: application to ocular hemodynamics

G Ninos, G Sofiadis, A Skouroliakou, IE Sarris - Symmetry, 2022 - mdpi.com
An algorithm for the calculation of steady-state flowing under uncertain conditions is
introduced in this work in order to obtain a probabilistic distribution of uncertain problem …